ISSN 2456-0235

International Journal of Modern Science and Technology


​​​​​​​April 2020, Vol. 5, No. 4, pp. 117-123. 

​​Effect of Methanolic Extract of Ginger (Zingiber officinale) on Lipids Profile, Liver Enzymes Activities and Kidney Functions of P407 induced Hyperlipidemic Albino Rats

E. U. Emmanuel¹*, I. Bawa¹, G. O. Ogo²
¹Department of Biochemistry Federal University of Agriculture Makurdi Benue State, Nigeria.

²Department of Biochemistry, Benue State University Makurdi, Nigeria.

​​*Corresponding author’s e-mail:


The aim of the research was to investigate the effect of methanolic extract of ginger (Zingiber officinale) on the liver enzymes activities, lipid profile, kidney function in P407 induce hyperlipidemic albino rats. Liver enzymes, lipid profile and kidney function activity of rat blood were measured. Liver enzymes activity increases from 15.23±2.22 to 110.30±3.22 and from 20.45±4.5 to 40.11±6.7 in AST and ALT enzymes respectively, a decrease was observed from 120.12±1.22 to 92.12±5.6 in the ALP enzymes activity. An increase in the lipid profile from 133.30 ± 33, 154.23±4.55, 104.10±1.23 ± 120.23 ± 4.5C and from 92.34±3.67 to 113.34±5.67 in TG, LDL and Cholesterol level. However, a significant decrease was observed in the HDL from 123.45 ± 3.4 to 80.01 ± 2.0­. An induction with poloxamer 407 led to an increase from 35.34±3.35 to 55.56±1.34 in Urea and from 1.33±0.45 to 4.54±0.50 in creatinine level respective. The findings of the study demonstrated that poloxamer 407 induced hyperlipidemia is associated with elevated lipids profile, liver enzymes and kidney disturbance, which were ameliorated by treatment with ginger.

Keywords: Zingiber officinale; Poloxamer; Methanolic extract; Lipid profile; Kidney function activity; Hyperlipidemia.


  1. Wang S, Zhang C, Yang G, Yang Y. Biological properties of 6-gingerol: a brief review. Natural Product Communications 2014;9(7):19-34
  2. Pillai AK, Sharma KK, Gupta VK, Barhshi S. Ginger: Pediatric Blood Cancer 2014;56:234-8.
  3. Mathew SJ, Kerridge S, Leptin M. Asmall genomicregion containingseveral loci required for gastrulation in Drosophila. Plosone 2009;4(10):7437.
  4. Sezgin Z, Yüksel N, Baykara T. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. European Journal of Pharmaceutics and Biopharmaceutics 2006;64(3):261-8.
  5. Dumortier H. Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. International Journal of Pharmaceutics 2016;241(1):47-55.
  6. Fung M, Hill J, Cook D, Frohlich J. Caseseries of type III hyperlipoproteinemia in children. Case Reports. Medical Publications, 2011. pp. 494-495.
  7. Liu Y, Leigh  JW, Brinkmann  H, Cushion  MT, Rodriguez-Ezpeleta  N, Philippe  H, Lang BF. Phylogenomic analyses support the monophyly of Taphrinomycotina, including Schizosaccharomyces fission yeasts. Molecular Biology and Evolution 2009;26(1):27-34.
  8. Knekt P, Jarvinen R,  Reunanen A, Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. British Medical Journal 1996;312:478-81.
  9. Khattab MM, Haseeb GM, Shaban AE, Arafa MA. Urea induced activity is couple to the synthesis of primary monoamine.A possible mechanism for the fertilization of mango. International Journal of Agricultural Technology 2007;10(6):1537-48.
  10. Agarwal R, Vishwanath G, Gary G, Gupta D. Randomized control of oral extract treatment for severe asthma with fungal sensation: Extract trial. Respiratory Clinical Medicine 2007;17(179):11-8.
  11. Hostettman K, Oliver P, Jean-luc W. The potential of higher plants as source of new drugs. CHIMIA International Journal for Chemistry 1998;52(1-2):10-7 
  12. Scmolka IR. Invivo and In vitro evaluation of pluronic F127-base ocular delivery system for timolol malware. International Journal of Pharmaceutics 1991;12(18):1-6
  13. Tiez NW. Clinical guide to laboratory test 2nd End. W.B. Saunders company, Philadelphia, USA 1990, pp: 554.
  14. Assman G, Jabs HU, Kohnert U, Nolte W, Schiewer H. LDL cholesterol determination in blood serum following precipitation of LDL with polyvinyl sulphate. Journal of Analytical Chimica Acts 1984;140:77-83
  15. Burstien M, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from serum by precipitation with polyanions. Scandinavian Journal of Clinical and Laboratory Investigation 1980;40:583-95.
  16. Friedwal WT, Levy RT, Fredrickson DS. Estimation of concentration of low density lipoproteins cholesterol in plasma without use of preparative centrifuge. Clinical Chemistry 1984;18:499-502.
  17. King EJ, Armstrong AR. A convenient method for determining serum and bile phosphate activity. Canadian Medical Journal 1964;7(31):376-81
  18. Hor SY, Farsi E, Yam MF, Nuyah NM, Asmawi MZ. Lipid-lowering effects of Coriolus versicolor extract in poloxamer 407-induced hypercholesterolaemic rats and high cholesterol-fed rats: Journal of Medicinal Plants Research 2011;5(11):2261-6.
  19. Victor DS, Dorcas BJ, Sunday EA. Ethanolic extracts of Vitex doniana possesses hepatocuractive property in poloxamer induced hyperlipidemia. Science Research 2014;2(3):49-54.
  20. Jibril Z, Malajiya IAS, Abdul Wahab A, Bello YA, Munira A et al. Hepatoprotective Effect of Camel Milk on Poloxamer 407 Induced Hyperlipidaemic Wistar Rats: International Journal of Toxicology 2012; 3(12):23-34
  21. Kim MS, Seo KS, Khang G, Cho SH, Lee HB. Preparation of poly (ethylene glycol)‐block‐poly (caprolactone) copolymers and their applications as thermo‐sensitive materials. Journal of Biomedical Materials Research Part A 2014;70(1):154-8.
  22. Kundu NK, Ullah MO, Hamid K, Urmi KF, Bulbul IJ, Khan MA, Akter M, Choudhuri MS. Studies of Lipid Profile, Liver Function and Kidney Function Parameters of Rat Plasma after Chronic Administration of Sulavajrini Vatika. Pakistan Journal of Biological Science 2015;23(12):11-23.