​​​​​​​​​​​​​November 2018, Vol. 3, No. 11, pp. 220-229. 

​​​Current Pharmacological Status of Cardioprotective Plants against Doxorubicin-Induced Cardiotoxicity: A Scoping Review

T. Gouri Sai Kiran*, K. Raj Kiran, M. Vinodkumar
Department of Pharmacology, Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India-530049.

​​​*Corresponding author’s e-mail: tgsaikiran@gmail.com

​Abstract

​Cardiovascular disease is the leading cause of morbidity and mortality in the world. Cardiotoxic effects can lead to heart failure, the inability of the heart to pump enough blood throughout the body which is due to cardiomyopathy. The present review is focusd on the plants that have been evaluated for cardioprotective activity against doxorubicin-induced cardiotoxicity. This review is based on pertinent papers that were retrieved by a selective search using relevant keywords in PubMed and Science Direct. The literature mainly focusing on natural products and herb extracts with therapeutic efficacies against experimental models both in vitro and in vivo was identified. Three phase screening was applied to select the most relevant studies that suit the objective of the review. Current evidence revealed that multiple molecules and signaling pathways, such as oxidative stress, iron metabolism, and inflammation, are associated with Doxorubicin (DOX) induced cardiotoxicity. Based on this knowledge, various strategies were proposed, and thousands of compounds were screened. A number of herbal extracts and natural products demonstrated potency in limiting DOX cardiotoxicity toward cultured cells and experimental animal models. This review, therefore, provided a useful resource to enable a thorough assessment of the profile of plants that have cardioprotective activity against doxorubicin-induced cardiotoxicity.

Keywords: Cardioprotective; Plants; Doxorubicin; Cardiotoxicity; Antioxidants.

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International Journal of Modern Science and Technology

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ISSN 2456-0235