ISSN 2456-0235

International Journal of Modern Science and Technology


​​​​​​​June 2020, Vol. 5, No. 7, pp. 172-181. 

​​Phytochemical Analysis and effect of methanolic root extract of Moringa oleifera on Haematological parameters and Body weight in poloxamer 407 Induced hyperlipidemic albino rats

Itodo Matthew Ocheleka¹*, Inalegwu Bawa², Agnes Ogbene Abutu³
¹Department of Biochemistry, Federal University of Agriculture Makurdi, Benue State, Nigeria.
²Department of Biochemistry, Federal University of Agriculture Makurdi, Benue State, Nigeria.

³Plataue State College of Health Technology, Zawan, Plataue State, Nigeria.

​​*Corresponding author’s e-mail:


The present research was aimed to study the phytochemical analysis and effect of methanolic root extract of Moringa oleifera on Haematological parameters and Body weight in Poloxamer 407 induced Hyperlipidemic Albino rats. Albino rats were grouped into 8; Group 1: Normal control given only food and water, Group 2: Hyperlipidemic control not treated, Group 2 to 8 was induced with Poloxamer 407 1000 mg/kg body weight, and however group 3 was treated with standard drugs atorvastatin (10 mg/kg). Group 4 treated with crude root extract (200 mg/kg) of Moringa oleifera and group 5 to 8 were treated with purified fraction from column chromatography. The study showed the multiple biological activities including antilipidemic, hepatoprotective, antiatherosclerotic, oxidative DNA damage protective, cardioprotective, as well as folk medicinal uses of Moringa oleifera root are attributed to the presence of functional bioactive compounds, such as flavonoids, alkaloids, saponins, tannins, cardiac glycoside. The methanolic root extract at 200 mg/kg body weight significantly (p≤0.05) increase packed cell volume (PCV), haemoglobin (Hb), and significantly (p≥0.05) decrease white blood cell (WBC) of the treated groups. This study supports the popular sayings about the tradomedicinal use of Moringa oleifera in the treatment of cardiovascular and other related diseases.  However it can be used in optimal concentrations to sustain animals infected with abnormal lipid in the absence of synthetic chemical drugs to prevent death to cardiovascular disease.

Keywords: Moringa oleifera; Poloxamer 407; Phytochemical analysis; Haematology; Body weight.


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