ISSN 2456-0235

International Journal of Modern Science and Technology


​​​August 2019, Vol. 4, No. 8, pp 192-195. 

​​Effect of Nutraceuticals of Dried Date Palm (Phoenix dactylifera) Fruit on Streptozotocin Induced Diabetes mellitus in Albino Rats

A. Sylvester, I. Bawa
Department of Biochemistry, Federal University of Agriculture, Makurdi, Benue State, Nigeria.

​​*Corresponding author’s e-mail:


Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. A nutraceutical is any substance that is a food or part of food that provides medical or health benefits. This research was targeted to approaching the problem of diabetes mellitus in developing countries like Nigeria by studying the neutraceticals of date palm fruits for their potentials in combating diabetes mellitus. The plant material was collected, identified and extracted using organic solvents (petroleum ether and methanol. Experimental animals (Albino Wister rats) were induced with diabetes mellitus using streptozotocin and treated with the crude extract and the various purified fractions. The treatment with the bioactive compounds showed a significant (P < 0.05) reduction in the treatment groups 3, 4 and 5(131.20± 2.49, 133.60± 6.50 and 123.40± 3.58) when compared with the control groups 1 and 2(111.00± 5.29 and 195.60± 12.38). The neutraceuticals at the dose of 400 mg/Kg body weight were able to reduce hyperglycemia. It is therefore possible to say that the neutraceuticals present in P. dactylifera fruit extract are anti-diabetic agents as seen by the significant changes in the study.

Keywords: Neutraceuticals; Diabetes mellitus; Date palm fruit; P. dactylifera; Hyperglycemia.


  1. American Diabetes Association, 73rd scientific sessions, 2013.
  2. Piero MN, Nzaro GM, Njagi JM. Diabetes mellitus- a devastating metabolic disorder. Asian Journal of Biomedical and Pharmaceutical Sciences 2014;4(40):1- 7.
  3. Manishal P, Rohit KV, Shubhini AS. Nutraceuticals: New era of medicine and health. Asian Journal of Pharmaceutical and Clinical Research 2010;3:1-5.
  4. Faqir MA, Sardar IB, Ahmad HE, Muhammad IK, Muhammad N, Shahzad HM, Sajid A. Phytochemical characteristics of date palm (phoenix dactylifera) fruit extract. Pakistan Journal of Food Sciences 2012;223:117-27.
  5. Choudhary KA, Bandyopadhay NG. Preliminary studies on the inorganic constituents of some indigenous hyperglycemic herbs on oral glucose tolerance test. Journal of Ethnopharmacology 1999;64:179-84.
  6. Khattab FKI. Histological and ultra-structural studies on the testis of rat after treatment with aluminum chloride. Australian Journal of Basic and Applied Sciences 2007;1(1):63-72.
  7. Agarwal MK, Ruhul AR, Agarwal ML. DNA replication licensing factor minichromosome maintenance deficient 5 rescues p53-mediated growth arrest. Cancer Research 2007;67(1):116-21.
  8. Akbarzadeh A, Norouzian D, Mehrabi MR, Jamshidi Sh, Farhangi A, Allah A, Mofidian S, Lame B. Induction of diabetes by streptozotocin in rats. Indian Journal of Clinical Biochemistry 2007;22(2):60-4.
  9. Trindler P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem. 1969;6:24-7.