August 2019, Vol. 4, No. 8, pp 192-195.
Effect of Nutraceuticals of Dried Date Palm (Phoenix dactylifera) Fruit on Streptozotocin Induced Diabetes mellitus in Albino Rats
A. Sylvester, I. Bawa
Department of Biochemistry, Federal University of Agriculture, Makurdi, Benue State, Nigeria.
*Corresponding author’s e-mail: email@example.com
Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. A nutraceutical is any substance that is a food or part of food that provides medical or health benefits. This research was targeted to approaching the problem of diabetes mellitus in developing countries like Nigeria by studying the neutraceticals of date palm fruits for their potentials in combating diabetes mellitus. The plant material was collected, identified and extracted using organic solvents (petroleum ether and methanol. Experimental animals (Albino Wister rats) were induced with diabetes mellitus using streptozotocin and treated with the crude extract and the various purified fractions. The treatment with the bioactive compounds showed a significant (P < 0.05) reduction in the treatment groups 3, 4 and 5(131.20± 2.49, 133.60± 6.50 and 123.40± 3.58) when compared with the control groups 1 and 2(111.00± 5.29 and 195.60± 12.38). The neutraceuticals at the dose of 400 mg/Kg body weight were able to reduce hyperglycemia. It is therefore possible to say that the neutraceuticals present in P. dactylifera fruit extract are anti-diabetic agents as seen by the significant changes in the study.
Keywords: Neutraceuticals; Diabetes mellitus; Date palm fruit; P. dactylifera; Hyperglycemia.