ISSN 2456-0235

International Journal of Modern Science and Technology


​​​​​​​​​​December 2018, Vol. 3, No. 12, pp. 241-252. 

​​​Chondroprotective effect of Glucosamine sulfate and Chondroitin sulfate in Osteoarthritis: A Review

O. Anusha, T. Baral, K. Raj Kiran, M. Vinod Kumar
Department of Pharmacy Practice, Vignan Institute of Pharmaceutical Technology,Visakhapatnam, Andhra Pradesh, India- 530049.

​​*Corresponding author’s e-mail:


Aim of the study is to review the chondroprotective effect of glucosamine sulfate (GS) and chondroitin sulfate (CS) in osteoarthritis (OA). The search terms included in this review are glucosamine, chondroitin, and osteoarthritis. We performed a literature review using electronic databases PubMed, Biomed Central, Science Direct and JAMA. The inclusion criteria are studies of OA of knee and hip, research articles, human studies and Quality of life of OA patient. The exclusion criteria are editorials, letters to editor, review articles, commentaries, conference presentations, comorbid conditions (e.g. cancer, rheumatoid disease), other nutraceuticals and animal studies. A three-phase process was performed in screening the articles. Two in-vitro studies stated that the combination of glucosamine and chondroitin had a positive effect in treating osteoarthritis and one in-vitro study provided novel evidence of anti-angiogenic, anti-inflammatory and anti-catabolic properties of CS and chondrocyte changes by chondroitin. Three studies showed the benefit of using GS in treating osteoarthritis and among three, one study showed that GS reduced the use of NSAIDs. Four studies stated that a combination of GS and CS showed improvement in treating osteoarthritis and among them one study showed that usage of CS results in significant improvement in knee joint swelling. There are studies showing benefits of glucosamine and chondroitin supplementation for people suffering from osteoarthritis. Based on in vitro and human studies discussed in this review, it has been suggested that glucosamine and chondroitin sulfate may be effective in preserving cartilage and might slow down disease progression.

Keywords: Glucosamine, Chondroitin; Osteoarthritis; Chondroprotective.


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