ISSN 2456-0235

International Journal of Modern Science and Technology


International Journal of Modern Science and Technology, 1(4), 2016, Pages 121-128. 

Microwave Assisted Synthesis, Characterization and Biological studies on 1,3,4-Thiadiazinan-5-one derivatives

S. Srinivasan, R. Girija
Department of Chemistry, Queen Mary’s College (Autonomous), Chennai, India.

Heterocyclic compounds play an important role as the main sources of lead molecules of agrochemicals. The 1,3,4-thiadiazinan-5-one nucleus is one of the most important and well known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. To find the novel lead compounds with various biological activities a series of thiadiazinan-5-one were rationally designed and synthesized. In this study an effort is made to synthesize 1,3,4-Thiadiazinan-5-one derivatives through the condensation reaction of Aryl aldehydes, substituted hydrazine derivatives and thioacetic acid using green solvent which is an efficient, green and facile three-component reaction. Using this method, 80% yield of thiadiazinan-5-one was obtained, while in conventional method, the yield only exceeded upto 50%. The chemical structures of the synthesized compounds were characterized by considering the data of their elemental analysis as well as their spectral data using, FT-IR, 1H-NMR, 13C-NMR and Mass spectra. The compounds are found to possess good biological activity. Especially, compounds were bearing the sulfur and nitrogen atoms showed activity than those bearing the oxygen atom.

​​Keywords: ​Microwave; Aryl aldehyde; Thioacetic acid; Hydrazine; Antimicrobial activity. 


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