International Journal of Modern Science and Technology
International Journal of Modern Science and Technology, 1(3), 2016, Pages 92-96.
Synthesis, characterization and anticancer activity of copper nanobiocomposite synthesized by leaf extract of Catharanthus roseus
G. Baskar, D. Sakthivel, Garrick Bikku George
Department of Biotechnology, St. Joseph’s College of Engineering, Chennai, 600119. India.
Nanotechnology has elevated the standards of treatment for various diseases especially cancer. The phytoconstituents of Catharanthus roseus can be used as antimicrobial, antioxidant, antifeedent, antisterilty and anticancer agents. It has high alkaloid content where more than 70 types where monoterpene indole alklaloids, vinblastine and vincristine can be used for the treatment of leukemia in children, breast and lung cancer. Copper oxide nanoparticles have gained received greater attention due to their promising properties. In the present work, copper nanocomposite was biosynthesized by the aqueous leaf extract of Catharanthus roseus. The biologically reduced copper bound alkaloid (phytoconstituent) nanocomposite was confirmed by UV spectroscopy, the functional group present in the nanocomposite was analyzed using Fourier Transform Infrared Spectroscopy, crystalline structure of the nanocomposite was characterized using X-ray diffraction crystallography. The anticancer activity against MCF-7 cell line was studied.
Keywords: Copper nanocomposite; Biosynthesis; Catharanthus roseus; Characterization; Anticancer activity.
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